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The Rho-GEF family (Rho-guanine nucleotide exchange factors) includes Dock1 (Dock180)-related proteins, although Dock 1 has no PH/DH (pleckstrin homology/Dbl-homology) domains but exhibits the DHR-1/DHR-2 evolutionary proteins region

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Additionally, cadmium induces oxidative stress in both somatic and germ cells, triggers inflammation, promotes apoptosis in germ cells, and exerts epigenetic modifications (55, 56)