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Acute Fat Oxidation and Energy Expenditure Acute single administration of AOD9604 in wild-type mice produced a significant increase in fat oxidation and energy expenditure, with an associated reduction in glucose oxidation

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Phase 1 corresponds to a high level of activity in the primary afferent as a result of C-fiber activation due to peripheral stimulation, whereas phase 2 results from a continuous low-level small afferent input, together with a facilitated state of spinal processing [21]