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Beyond systemic symptoms, vitamin B12 deficiency is also associated with a range of oral manifestations, including burning mouth syndrome, recurrent aphthous ulcers, mucosal inflammation, and trigeminal nerve-related pain, which are often underdiagnosed or misattributed to other conditions (Bao et al., 2021

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A 2024 paper then reported that MOTS-c modulates skeletal muscle function by binding and activating the enzyme CK2 in laboratory models