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The system leverages tumor-specific GSH reduction of Pt(IV) to Pt(II), amplifying H 2 O 2 production while Mn 2+ catalyzes •OH generation through Fenton-like reactions, creating a self-amplifying ferroptosis–ICD cycle (Fig

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As a constantly active organ, the myocardium has a remarkably high density of mitochondria, and therefore has a remarkably high rate of oxygen consumption and a correspondingly high level of basal ROS production [108,109]