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(ii) AGK was discovered as a multi-substrate lipid kinase (among which 2-AG) [151,152], is involved in cell proliferation and cancer [152,153], protein import into mitochondria [154], thrombopoiesis and thrombosis [155,156], and antitumor activity of CD8 T-cells [157], and is mutated in a rare recessive autosomal disease called Sengers syndrome [158]