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It is proposed to stimulate lipolysis and inhibit lipogenesis without meaningfully raising IGF-1, but this mechanism has been demonstrated primarily in rodent models

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Some studies have used endogenous small interfering RNAs (miRNAs) to inhibit NNMT and competitive endogenous RNAs (ceRNAs) as “sponges” of miRNAs to reduce the inhibitory effect of miRNAs on target genes