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However, a caveat to this interpretation and other studies mentioned here is that subjects classified as susceptible to addiction also consistently consume more drug over time than their less-susceptible counterparts

Vitality & Longevity

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Further investigation highlighted a role of hypoxia-inducible factor (HIF)-1α in these effects, as knockdown of HIF-1α reversed the H 2 S-induced EMT phenotype (Wang, Yan et al