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The aims of this study were to establish a rat model of antenatal opioid dependence and neonatal acute opioid withdrawal (Experiment 1) and to evaluate the effects of NAC on acute opioid withdrawal in the neonatal rat on outcomes of withdrawal behavioral scores and central nervous system (CNS) metabolism (Experiment 2)

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Animal studies have reported improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, liver fat, and liver triglycerides following NNMT inhibition