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Moreover, signs of microglia activation as well as increased inflammatory cytokines and chemokines (i.e., interferon (IFN)γ, interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF), and chemokine C-C motif ligand (CCL)-2) have been found in the brains and cerebrospinal fluid of ASD subjects [20,41]

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Analogously GH deficiency in rodents is associated with delayed sexual maturation [7, 18], and GnRH immunoneutralization delays sexual maturation in rats and reduces testicular mass, spermatogenesis, and follicle-stimulating hormone responsiveness [19]

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