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This is why oral peptide supplements are largely inert unless specifically engineered with protease-resistant modifications or encapsulation

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Besides biological systems similarly altered in vitamin D deficiency and RLS, the role of vitamin D in the modulation of neurotransmitters reportedly altered in RLS, might indicate a rationale to consider D3 supplementation, at least as an add-on therapy, in resistant RLS with known vitamin D deficiency, once all other traditional RLS therapeutic options have been exploited