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Methylcobalamin is the naturally occurring, active form of Vitamin B12. Unlike synthetic forms (such as cyanocobalamin), which the body must actively convert before using, methylcobalamin is ready to be absorbed and utilized immediately, offering faster and more reliable energy support
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cyanocobalamin) ranged from 20 mcg to 1,840 mcg daily.(10,13) Methylcobalamin dosage was between 4 mg and 1,500 mg daily.(11,12) The duration of therapy in the four studies varied from 12 weeks(13) to 16 weeks(10,12) and 24 weeks.(11) In Fonseca et al’s study, compliance to therapy was checked through the measurement of changes in the serum level of vitamin B 12 as prescribed to the participants.(11) Farvid et al supplemented this with capsule counts and individual sessions with skilled counsellors, who promoted compliance to the intervention at regular intervals.(10) Two of the studies did not mention how compliance to therapy was ensured.(12,13) The main outcomes in the selected RCTs can be grouped into electrophysiological measures (namely VPTs and/or nerve conduction velocities) and neuropathic symptoms