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Frontiers | Food-derived compounds targeting ferroptosis for cancer therapy: from effects to mechanisms

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For example, the multifunctional nano-epigenetic inhibitor CREDIT composed of polymeric polylactic acid-glycolic acid (PLGA) grafted with histidine (PLGA-his) loaded with the epigenetic inhibitor TMP195, modified with red blood cell membranes and conjugated with the TAM-targeting peptide CRV, can reprogram M2-type TAMs into the M1 phenotype, reduce MDSCs, increase the number of T cells in tumors and inhibit tumor growth (215)