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The endocannabinoid system comprises (i) the endocannabinoids [natural cannabinoid substances in the body including 2-AG and arachidonoyl ethanolamide (anandamide)], (ii) enzymes involved in endocannabinoid synthesis and catabolism that regulate their concentration in the brain, and (iii) the cannabinoid receptor types 1 and 2 (CB 1 and CB 2 ) which transmit their signals in tissues and organs (Figure 2) [8]

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