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GPCR Desensitization: Acute and Prolonged Phases - PMC

Analysis of ileal fluid collected from ileostomists after the ingestion of various foodstuffs has shown that even when dietary (poly)phenols are absorbed in the proximal GIT, substantial quantities nonetheless pass from the small to the large intestine (220, 235, 236, 294), where the colonic microbiota cleave conjugating moieties, and the resultant aglycones undergo ring fission leading to the production of smaller molecules, including phenolic acids and hydroxycinnamates

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Nature Chemical Biology, 5, 575–577