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Notably, Trim21 knockdown further enhanced tumor growth in the Fgl1 /WT group ( Fgl1 /WT_ Trim21 KD), but not in the Fgl1 /K161R group ( Fgl1 /K161R_ Trim21 KD) (Fig

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The RESILIENCE study, a randomized, double-blind, placebo-controlled, phase III trial, revealed a lack of survival advantage for combining sorafenib with capecitabine or placebo in patients with locally advanced or metastatic HER2-negative breast tumors (Decker et al., 2017)