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Common issues include gastrointestinal (GI) discomfort, such as nausea, vomiting, diarrhea, and constipation, especially in GLP-1 receptor agonists like semaglutide and liraglutide

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(1) Neurodevelopmental Homeostasis: In the healthy state, mitochondrial oxidative phosphorylation (Complexes I–V) supports efficient ATP generation, redox stability, and formate flux from the mitochondrial folate cycle (via SHMT2, MTHFD2)