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( RNA-sequencing of microglia in the optic nerve head of DBA/2J mice at an early time point (when IOP is high, but there is no detectable optic nerve degeneration) demonstrates that microglia also undergo an early disruption to the regulation of their metabolism ( Hif1a expression, a master regulator of glycolysis, which is known to change in response to (oxidative) stress and inflammation

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2022;23 doi: 10.3390/ijms23136879