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Group A included 77 participants aged 50.2±9.8 years, 65(84.4%) men, MELDNa 14.0±3.5 with median carvedilol dose 6.25mg & ivabradine 7.5mg qd, while Group B included 76 participants aged 50.1±9.6 years, 59(77.6%) men, MELDNa 13.7±3.1 with median carvedilol dose 6.25mg qd

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Lower cagrilintide doses in combinations When combining, can reduce cagrilintide: 1.8mg cagrilintide + 2.4mg semaglutide: Still very effective (14-18% weight loss estimated) Better tolerated than both at 2.4mg Cost savings on cagrilintide Consider if GI-sensitive 1.2mg cagrilintide + 2.4mg semaglutide: Modest benefit from cagrilintide addition Minimal GI side effects from cagrilintide Semaglutide does heavy lifting May still achieve 12-15% total weight loss Testing approach: Start with standard doses (both 2.4mg) If intolerable, reduce cagrilintide first Maintain semaglutide at 2.4mg (well-tolerated, established) Find optimal cagrilintide dose for your tolerance Maintenance dosing after weight loss Strategies to sustain results long-term