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However, the majority of studies examining the associations of these B-vitamins with depression are cross-sectional and have not controlled for important covariates, such as disease status, medication use or vitamin D status, which has been shown to an important predictor of depression (Reference Briggs, McCarroll and O’Halloran20)

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Role of N-acetyl-p-benzoquinone imine formation and glutathione." The Journal of Pharmacology and Experimental Therapeutics, 187(1), 211-217