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Contrary to the increase in homocysteine levels that is stated above, a cross-sectional study that concluded 1111 patients with type 2 diabetes who took metformin for at least 6 months reported that homocysteine levels were negatively correlated with vitamin B 12 levels, and suggested a hypothesis that B 12 deficiency due to the use of metformin occurred at the tissue level [40]

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Functional genomic analysis in arthritis-affected cartilage: yin-yang regulation of inflammatory mediators by alpha 5 beta 1 and alpha V beta 3 integrins