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Secondly, curcumin could easily cross the tight junction of BBB as this is important to ensure effective pharmacokinetic actions in CNS

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10.3390/antiox10122031 [DOI] [PMC free article] [PubMed] [Google Scholar] Zelko IN, Mariani TJ, Folz RJ (2002) Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression