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At the outset, we analyzed and contrasted the expression variations of signature genes and clinical attributes between the two risk groups, subsequently presenting the findings through a heatmap visualization ( Figure 7a )

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Pathway 4 — Amylin (Cagrilintide) Amylin receptors (AMY1R, AMY3R — heterodimers of the calcitonin receptor with RAMP1/RAMP3) are activated primarily in the area postrema, with secondary action in the NTS (Lau et al., 2021)