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However, the darker side of this mechanism in chronic alcohol consumption, as seen in ALD, is the resultant buildup of acetaldehyde, a toxic metabolite that triggers inflammatory processes by activating Kupffer cells and drawing neutrophils into the liver [201]

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[DOI] [PubMed] [Google Scholar] 116.Virdis A., Lerman L.O., Regoli F., Ghiadoni L., Lerman A., Taddei S