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Overall, these findings provide substantial evidence for the role of ROS in inducing apoptotic cell death, establishing that ROS are as a promising pathway in tumor therapy

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Although all Igs have two binding sites, differences in epitope location also affect the ability of antibodies to cross-link another AChR, so not all antibodies have the function of cross-linking with the receptors to induce their internalization and eventual degradation (Conti-Fine et al., 2006)