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Sonya Hessey Abigail Bunkum Mariam Jamal-Hanjani Article Open Access Clinical application of base editing for treating β-thalassaemia A clinical phase 1 trial of a single infusion of CS-101, CD34 + cells modified using a transformer base editor to reactivate fetal haemoglobin production, led to early and enduring transfusion independence in patients with β-thalassaemia

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This type of cell death can be completely blocked by Ferr‐1 but cannot be inhibited by Nec‐1s, an inhibitor of apoptotic necrosis 6