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Based on a competitive inhibition mechanism, adding supraphysiological concentrations of glutamine (SPG) inhibited the uptake of neutral amino acids in oocytes expressing human SLC1A5 (ASCT2), the primary glutamine transporter in cancer cells [92,93]
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In this study, we demonstrated that cystine decreased the intracellular GSH/GSSG ratio in Salmonella , which disrupted cellular redox homeostasis, increased ROS production, and activated the Fenton reaction, thereby enhancing the bactericidal effect of gentamicin on drug-resistant bacterial strains