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12 Apart from its canonic role in inflammation responses,13, 14, 15, 16 Bcl3 has also a distinct function in immunomodulation, 11 , 17, 18, 19, 20 cellular development,21, 22, 23, 24 and metabolic pathways.25, 26, 27 It is intriguing that Bcl3 exhibits either pro-inflammatory or anti-inflammatory roles in different microenvironments