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In the pathway analysis considering their p -values, the top 15 impact metabolic pathways belong to lipid metabolism, primary bile acid biosynthesis, purine metabolism, arginine and proline metabolism, steroid biosynthesis, d-glutamine and d-glutamate metabolism, taurine and hypotaurine metabolism, nicotinate and nicotinamide metabolism, glycerolipid metabolism, steroid hormone biosynthesis, tryptophan metabolism, galactose metabolism, glycerophospholipid metabolism and glutathione metabolism