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This supports the notion that plasma Hcy is a more specific marker for overall functional folate status and indicates that baseline Hcy might be useful in predicting toxicity during pemetrexed therapy or be used as support for increased supplementation (either duration or dose) in individuals in whom Hcy remains elevated after initial supplementation

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PMID: 117 HayashiMNakashimaTYoshimuraNOkamotoKTanakaSTakayanagiH