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Although PIF4, a canonical bHLH TF, carries the expected machinery for both tasks—an arginine-rich DNA-binding motif and an acidic TAD—our results indicate that in contexts where partner factors are available, PIF4 variants with disrupted DNA-binding or transactivation activity still support thermosensory gene expression and hypocotyl growth, consistent with partner-enabled compensation

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NAC vs Glutathione: 4 Key Factors to Guide Your Antioxidant Decision The decision between NAC and Glutathione depends on your individual health needs and goals