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Considerations for Clinical Adoption: Evidence, Safety, and Regulatory Landscape Despite encouraging preclinical findings and increasing patient enthusiasm, the integration of peptide-based therapies in mainstream orthopaedic practice remains cautious

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TB-500 promotes angiogenesis through PI3K/Akt-mediated endothelial cell migration and tube formation, upregulation of angiogenic growth factors, and the actin cytoskeletal dynamics that drive endothelial cell migration into avascular tissue