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32,35,215 However, at relatively high doses, methotrexate is also known to trigger a pro-oxidant state which further contributes to the structural and functional alteration of critical cell components, for example, lipids, proteins and DNA

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he has received a grant, paid to his institution, from Boehringer Ingelheim and holds the position of Director, Preventive Cardiology, at Brigham and Women’s Hospital