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Firstly, copper (Cu) can directly bind to cysteine residues on glutathione peroxidase 4 (GPX4), leading to abnormal aggregation of GPX4 (Xue et al., 2023a), loss of its antioxidant activity, and the initiation of GPX4 autophagy-related reactions via the TAX1BP1 receptor

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Comment on Analyses and Conclusions of “Microglial activity in people at ultra high risk of psychosis and in schizophrenia: an [ 11 C]PBR28 PET brain imaging study”