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Genetic modulation further validates this axis: cartilage-specific GPX4 knockout exacerbates experimental OA, whereas overexpression of GPX4 or SLC7A11, or silencing of pro-ferroptotic genes (e.g., TFR1, ACSL4), robustly suppresses chondrocyte ferroptosis and attenuates joint pathology (Wang S

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As a result, it has been gradually replaced by other phototherapy techniques

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