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We explained our belief that if an ACO fails to meet both standards, it would be appropriate for CMS to take one of the actions described at § 425.216 (provide a warning notice to the ACO, request a corrective action plan from the ACO, or place the ACO on a special monitoring plan) for noncompliance with the quality performance standards

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Tube formation assay HUVEC cells from the 3rd to 5th generations were starved for 24 h