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The BM microenvironment can also play a role in leukemia drug resistance, mediated by a diverse set of mechanisms, both by direct cell adhesion271311 and/or soluble factor release.29282012 In this study, the protective effects of MSC against PTL toxicity were related to decreases in ROS stress and preserved rGSH levels, suggesting that MSC increased the anti-oxidative stress capacity of T-ALL cells and thereby conferred resistance to PTL

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Cytotoxic payloads The cytotoxic payload is the warhead that exerts cytotoxicity after internalization of BsADCs into cancer cells