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Tumor heterogeneity further complicates the development of SIRT1-targeted therapies, as the role of SIRT1 and autophagy can vary not only between different cancer types but also within different regions of the same tumor

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The catalytic triad at the GD is approximately 40 Å away from the PP-loop, SGGVDS, of the SD within the same monomer (Figure 2B)

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