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The HMP linker (2 eq.) and DIC (1.1 eq.) were dissolved in a minimum amount of DCM:DMF (4:1 v / v )

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In this study, CGA improved the activity of mitochondrial complexes I, IV, and V by enhancing the levels of SOD and mitochondrial glutathione in the brain, inhibited the activation of Bax and caspase-3 (proapoptotic proteins), increased the expression of Bcl-2 (an antiapoptotic protein), and prevented the MPTP-mediated apoptotic cascade