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Briefly, GH binding to preformed dimeric GHR - JAK2 complexes introduces structural changes in the receptor complex that separates JAK2 inhibitory and kinase active sites and enables trans-phosphorylation of the two JAK2 molecules (reviewed in (59)

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The combinatorial strategy increased the chemotherapeutic sensitivity of GC cells compared to Cis monotherapy Our prior findings demonstrated the synergistic tumor-suppressing effects of Cis and CAS in GC models, both in vitro and in vivo (Fig

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