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Therefore, we proposed to use our authority under section 1899(i)(3) of the Act to limit the amount of time an ACO may participate in the Shared Savings Program under a one-sided model and require ACOs to more rapidly progress to higher levels of risk and potential reward under a two-sided model

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We demonstrated that 7OH is a potent low-efficacy agonist at mMOR and hMOR in the efficacy range comparable to buprenorphine ( E max ~ 20% versus DAMGO), in a cell-based assay without signaling amplification (Nb33 BRET assay)