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This results in the typical features of TD, such as excitotoxicity and disruption of the blood–brain barrier (BBB), which allows the passage of many vascular factors from the systemic circulation to the brain, leading to the activation of microglia and the induction of apoptosis [40,110]

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The GLP1R agonist semaglutide inhibits reactive astrocytes and enhances the efficacy of neural stem cell transplantation therapy in Parkinson’s disease mice