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Supporting this hypothesis, dopamine-mediated inhibition of NLRP3 in murine macrophages was linked to cAMP activation, and dopamine-mediated inhibition of NF- κ B was associated with D1-mediated activation of PKA, a downstream effector of cAMP, in microglia and other cells lines (Takeuchi and Fukunaga, 2003

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International Journal of Radiation Oncology • Biology • Physics 99(2):E677-E677, 2017