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(2000) showed that high concentrations (1.5 mM) of the NO donors S -nitroso- N -acetyl-penicillamine (SNAP) and (Z)−1-[N-93-ammonio-propyl-N-(n-propyl)amino] diazen-1-ium-1,2 diolate (PAPA/NO) exacerbated tumor necrosis factor alpha (TNF-α) induced cardiac dysfunction and cellular injury in both isolated rat hearts (Langendorff model) and cultured cardiomyocytes 43

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If an atom/molecule contains one or more unpaired electrons and is capable of independent existence, it is referred to as a “free radical”(136)