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35,36 While TFs, kinases, and other classes of proteins such as chromatin readers have long been thought to be undruggable by small molecules, phenotype-based drug target identification together with structure-based rational design have proven to be powerful approaches to identify previously uncharted targets and to elucidate mechanisms of action (MoA) and cell signaling cascades

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But the researchers reporting the most dramatic metabolic changes are not running retatrutide alone