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While the specific roles and interactions of direct viral mechanisms, indirect effects mediated by the host immune response, and these other contributing factors in NeuroHIV pathogenesis remain complex and not fully elucidated, growing evidence increasingly highlights the central role of microglial activation and subsequent neuroinflammation

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The same SP-D fragment binds specially to apoptotic and necrotic alveolar macrophages in vitro , what suggests that SP-D contributes to lung immune homeostasis by recognizing and promoting removal of necrotic and apoptotic cells (315)