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Elevated cAMP activates protein kinase A (PKA), which phosphorylates and activates hormone-sensitive lipase (HSL) and other lipases responsible for hydrolyzing triglycerides

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A Phase 2 trial of topical GHK-Cu gel against vehicle placebo in standardized punch-biopsy wounds, 60 participants, sponsored by Hudson Biotech, has been recruiting since 2 February 2026 with primary completion scheduled for 14 February 2027.16 It is placebo-controlled and uses a standardized wound, which is more methodological rigour than this compound has received in thirty-four years