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Frontiers | Lithium and the Interplay Between Telomeres and Mitochondria in Bipolar Disorder

In the presence of cytokines and growth factors, STAT3 is phosphorylated by receptor-associated tyrosine kinases, and this phosphorylation allows STAT3 to form homo- or heterodimers that translocate to the cell nucleus, where they act as activators of transcription [210]

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Important safety considerations include a contraindication in patients with personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)