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What's more, the body loses fluids more quickly during exercise because it generates heat that's shunted to the skin's surface, where perspiration and subsequent evaporation (a cooling process) help with temperature regulation

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In conclusion, the hypoxia–HIF‐1α–VEGF pathway regulates inefficient vasculature, which sustains tumor cell metabolism, facilitates dissemination, and reinforces immunosuppression (117, 118)