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Unfortunately, when we infused IGF-1 LR3 at a dose of 6.78 μg·kg −1 ·h −1 (based on fetal weight of 0.852 kg at the time of necropsy), we observed fetal demise within 48 h of initiating treatment

DRB-00152

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INSULIN-GH-IGF AXIS PHYSIOLOGY, A PEDIATRIC PERSPECTIVE Insulin-GH-IGF-Axis and Human Fetal Growth IGF-I controls the pace of the cell cycle from early on in human embryogenesis