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Studies in animal models of renal insufficiency have demonstrated that GH or work overload-induced upregulation of IGF-1 expression in the skeletal muscle is partially reduced in animals with renal insufficiency.138 In the same way, a complementary study has shown that IGF-1, IGF-2 and IGF-1 receptor gene expressions are reduced in skeletal muscle from patients treated with hemodialysis as compare with normal control participant

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Therefore, B12 shots can be particularly beneficial for those experiencing neurological symptoms associated with B12 deficiency including chronic fatigue or cognitive problems